A REVIEW ON SOLID LIPID NANOPARTICLES AND ITS METHODS OF PREPARATIONS

Shweta Manoj Dhule*, Ramchandrapuram Devika, Ravi Mrudhula, Shaik Abdulrazak, S. Siva Sankar and S. Shiva Prasad

ABSTRACT

Solid lipid nanoparticles (SLN) are regarded as
the forefront of nanotechnology's fast evolving sector, with
numerous potential uses in drug delivery and research. SLN has potential characteristics for achieving the goal of
regulated and site specific drug delivery, and has so piqued the interest of ma ny researchers .SLNs have emerged as
effective vaccine delivery strategies. SLN based vaccines promote site specific transfer, antigen presentation,
innate immune response, robust T cell response, and safety against infectious illnesses, malignancies, auto immune
diseases, and neuro degeneration .This review discusses the morphology, structural properties, materials utilized in
manufacture, production processes, and characterisation utilizing various methods of nano structured lipid carriers
and SLNs.

Keywords: Bioavailability, Nanoparticles, Zeta potential, Electrostatic repulsion.