REVIEW: PHARMACOLOGICAL AND THERAPEUTIC EFFECTS OF TRIGONELLINE

Astikta Ashok Bhondave*, Aditi Rajaendra Waghmare, Dr. Hemant. V. Kamble and S. R. Ghodake

ABSTRACT

Trigonelline (TRG), is an alkaloid predominantly found in the seeds of Trigonella foenum-graecum and coffee. Which has therapeutic efficacy as a neuroprotective, anticancer, hypoglycemic, hypolipidemic, sedative, memory-enhancing, antibacterial, antiviral, and antitumor agent. TRG's biological activities center around glucose and lipid metabolic regulation, as well as anti-inflammatory and oxidative stress modulation. It shows multidimensional effects, including neuroprotection from neurodegenerative disorders and diabetic peripheral neuropathy, neuromodulation, mitigation of cardiovascular disorders, skin diseases, diabetic mellitus, liver and kidney injuries, and anti-pathogen and anti-tumor activities. TRG has various therapeutic effects on multiple pathological conditions, including metabolic syndrome, neurodegenerative diseases, cancers, and inflammation-associated disorders.

Keywords: Trigonelline (TRG), Pharmacological Activities, alkaloid, Therapeutic Effects.