CHARACTERIZATION AND BIOMEDICAL POTENTIAL OF SILVER NANOPARTICLE DOPED NANOHYDROXYAPATITE: A SYSTEMATIC REVIEW

Pavan A. Narote, Mansi M. Sonbansi, Shubhada A. Ganvir* and Dr. M. D. Kitukale

ABSTRACT

Silver nanoparticle (AgNP)
doped nanohydroxyapatite (nHA) has emerged as a promising biomaterial due to its
enhanced antimicrobial properties, osteogenic potential, and suitability for biomedical applications. This systematic
review explores the characteri zation techniques and biomedical potential of AgNP doped nHA by analyzing studies
published in leading scientific databases. Various synthesis methods, including chemical precipitation, sol gel, and
hydrothermal techniques, have been employed to develop Ag NP doped nHA, with characterization performed
using techniques such as X ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning
electron microscopy (SEM), and transmission electron microscopy (TEM). The review highlights that AgNP
incorporation significantly improves the antimicrobial activity of nHA, making it a suitable material for dental and
orthopaedic applications. Additionally, AgNPs enhance osteoblast proliferation and bone mineralization at optimal
concentrations (other biomaterials suggests that AgNP doped nHA offers superior antibacterial performance but may require
mechanical optimization for load bearing applications. Despite promising findings, challenges remain regarding
the long term biocompatibility, controlled silver ion release, and large scale production of AgNP doped nHA.
Future research should focus on optimizing synthesis parameters, evaluating long term in vivo effec ts, and
integrating the material into 3D printing technologies for patient specific applications. This review provides a
comprehensive understanding of the current state of AgNP doped nHA and its potential in biomedical applications.

Keywords: Silver nano particles, Nanohydroxyapatite, Antimicrobial biomaterials, Bone regeneration, Osteogenic potential, Characterization techniques, Biocompatibility, Drug delivery.