STRATEGIC OPTIMIZATION OF RAPIDLY DISINTEGRATING TABLETS UTILIZING BOX BEHNKEN EXPERIMENTAL DESIGN

Tushar Sonare, Aman Kumar, Kratika Khadsondni, Krutika Mandloi, Dr. Akash Yadav* and Dr. Dinesh Kumar Jain

ABSTRACT

This research thoroughly investigated the formulation of quickly disintegrating glipizide tablets, utilizing a Box
Behnken design in conjunction w ith the direct compression method. The study concentrated on using super
disintegrants such as cross povidone and sodium starch glycolate, paired with the binder hydroxypropyl
methylcellulose. Comprehensive pre formulation tests were carried out to confirm the physicochemical
compatibility of glipizide with the chosen excipients. The resulting fast dissolving tablets underwent rigorous
assessments, which included evaluating weight variation, mechanical strength, friability, disintegration time, in
vitro dru g release characteristics, and stability. By strategically applying the Box Behnken design, the optimization
of the synthetic super disintegrants' ratios led to enhanced disintegration and an optimal release profile for the
active pharmaceutical ingredient . This novel formulation of fast dissolving glipizide tablets is anticipated to greatly
enhance patient compliance, particularly for diabetic individuals who face challenges with swallowing, thereby
potentially improving treatment effectiveness and overall disease management.

Keywords: Glipizide, Box Behnken design, rapidly disintegrating.