SYNTHESIS AND HYPOGLYCEMIC EFFECT OF STILBENE DERIVATIVES

Malamine Mansaly, Fatimata Seydy Ball, Oumar Sambou, Charlot Diatta, Ramata Ousmane Diallo, Mamadou Fodé Camara, Henry Diassy, Michael Rivard, Guata Yoro SY* and Abdoulaye Gassama

ABSTRACT

The synthesis of stilbene derivatives via the Wittig reaction using Benzyl-triphenyl-phosphonium chloride was successfully carried out and seven (7) molecules were obtained. The products were characterized by MS and NMR analysis. The effect on blood glucose of its compounds was evaluated on wistar Kyoto rats. At the dose of 3 mg/kg per os, RD02 (anthraldehyde derivative) and RD05 (benzaldehyde derivative) induced a powerful and persistent hypoglycemic effect. The blood glucose respectively varied from 0.89±0.02 to 0.65±0.04 g/L (p<0.05, n=5) and 0.87±0.02 to 0.71±0.02 g/L (p<0.05, n=5). Under the same conditions, the similar hypoglycemic effect was observed with RD04 (benzaldehyde derivative) (0.67±0.04 vs 0.93±0.03 g/L) (p<0.05, n=5). Conversly, stilbenes derived from cinnamaldehyde (SS014, SS015) do not modify baseline blood glucose levels in normoglycemic rats. This study reports the synthesis of stilbene derivatives and its effects on blood glucose in normoglycemic rats. RD02, RD04 and RD05 are potential candidates for the synthesis of structural analogs of interest in blood glucose regulation.

Keywords: Wittig reaction, Anthraldehyde, Benzaldehyde, Cinnamaldehyde, Blood glucose.