INCREASED RISK OF CARDIAC DISEASE IN A PATIENT WITH HEMOPHILIA: A RARE CASE REPORT

Shreyaa Datta*, Debjit Bhakat, Nungshichila A. Jamir, Arindam Dey, Dimple G., Anirban Debnath and Harshdeep Sarva

ABSTRACT

This is the case report of an unusual clinical situation, one in which a 49-year-old man with hemophilia A presented with acute coronary syndrome. Managing his case required extreme caution in balancing the risks of thrombosis and bleeding. A successful outcome was secured through a multidisciplinary treatment approach, which included Factor VIII replacement therapy in combination with modified antiplatelet therapy; percutaneous coronary intervention (PCI) was done using a bare metal stent (BMS) to limit prolonged dual antiplatelet therapy (DAPT). Careful management post-procedure, which consisted of individualized anticoagulation strategies and cardiovascular risk factor modification, helped to achieve a favorable outcome. This case showcases the higher incidence of cardiovascular events among hemophilia patients, underscoring the need for alternative treatment paradigms. Such collaborations among hematologists and cardiologists will serve well to advance the fine line between hemostasis and thrombosis. Clinical studies are needed to optimize antithrombotic approaches in this population.

Keywords: Hemophilia, cardiovascular disease, coronary artery disease, bleeding risk, antiplatelet therapy, Factor VIII replacement, percutaneous coronary intervention, thrombosis, multidisciplinary approach.