A REVIEW ON ADVERSE DRUG REACTION AT PRESENT DAY’S AND THEIR CLINICAL CONSEQUENCES

Mousumi Das, Manonayan Singha, Mir Irfan Soyel*, Malay Besra, Deepayan Kar, Biplab Kumar Chakra, Nilanjan Adhikari

ABSTRACT

Significant patient morbidity and death as well as financial strain on the healthcare system are caused by adverse medication reactions. Anaphylaxis and malignant hyperthermia continue to be the two most worrisome adverse medication responses for anesthetists. Anaphylaxis under anesthesia is so common that most anesthetists will handle at least one case during their careers, despite the fact that its incidence is difficult to determine. Numerous medications administered during the preoperative phase and the anesthetized patient's fluctuating presentation might cause delays in diagnosis and treatment, as well as negatively impact the result. Furthermore, because adverse effects may be mediated by mechanisms other than IgE activation, causative medicines can still be challenging to identify despite advancements in testing. Anesthetists‘ must stay current on new advances because of the rise in allergy reports to newer anesthetic medications like sugammadex and the shift in the most likely causal peri-operative substances during the past few decades. To help reduce the likelihood of a reaction, they should also be aware of patient features, such as pharmacokinetic abnormalities that may predispose to adverse medication reactions. Morbidity and mortality are still high because to the severity of adverse pharmacological reactions to preoperative medications.

Keywords: Adverse drug reaction, Risk Factors for ADR, Drug Hypersensitivity Reactions, Diagnostic and Therapy for Drug Hypersensitivity, Penicillin allergy.