MICROSPONGE DRUG DELIVERY SYSTEM: AN OVERVIEW

Shital S. Patil*, Vaishali Dandekar, Asawari Kale and Dr. S. D. Barhate

ABSTRACT

The Microsponge Delivery System (MDS) is a patented polymeric system consisting of porous microspheres. They are tiny sponge like spherical particles that consist of a myriad of interconnecting voids within a non-collapsible structure with a large porous surface through which active ingredient are released in a controlled manner. Microsponges are porous microspheres having myriad of interconnected size ranging voids of particle from 5-150 μm. The area of drug delivery technology is evolving rapidly and becoming highly competitive day by day. The developments in the delivery systems are being utilized to optimize the efficacy and the cost effectiveness of the therapy. These microsponges have the capacity to entrap a wide range of active ingredients such as emollients, fragrances, essential oils, sunscreens and anti-infective, etc. are used as a topical carrier system. these porous microspheres with active ingredients can be incorporated in to formulations such as creams, lotions and powders. Microsponges consisting of noncollapsible structures with porous surface through active ingredients are released in a controlled manner. Release of drug into the skin is initiated by a variety of triggers, including rubbing and higher than ambient skin temperature.

Keywords: Microsponge, porous microspheres, Microsponge Delivery System (MDS), Pharmaceutical product.