GREEN SCALABLE APPROACH FOR DEVELOPMENT AND ASSESSMENT OF CUSTOMIZED TABLETS INVOLVING BOX BEHNKEN DESIGN

Kratika Khadsondni, Krutika Mandloi, Tushar Sonare, Aman Kumar, Dr. Akash Yadav* and Dr. Dinesh Kumar Jain

ABSTRACT

One billion people worldwide suffer from hypertension, a condition that requires efficient and patient-friendly treatment options. In this work, propranolol hydrochloride, a beta-blocker often used to treat hypertension, is developed as a mucoadhesive bilayer tablet formulation. A mucoadhesive extended-release layer for prolonged medication administration and an immediate release layer for a quick therapeutic impact are both included into the suggested tablet form. A scalable and economical production technique, the direct compression method, was used to prepare both layers. Pre- and post-compressional characteristics were thoroughly evaluated to ensure the tablets fulfilled the necessary quality requirements. Additionally, a response surface approach called the Box-Behnken design was used in the study to improve the formulation. Desired results were shown by the optimized batch, MBT 16, which showed efficient drug release for both immediate and long-lasting effects. Propranolol hydrochloride's pharmacokinetic profile is improved by this innovative dual-layer technique, which may increase patient compliance by lowering dosage frequency while preserving steady blood pressure management all day. The formulation's affordability and safety are further demonstrated by the use of natural excipients. Through creative medication delivery methods that combine therapeutic efficacy with enhanced patient adherence, this study opens the door for more sophisticated hypertension therapy.

Keywords: Customized Tablets, Green approach, Propranolol HCl, Design expert, Box Behnken Design, Chia Seed Mucilage, Aloevera Extract, Potato Starch.