ANTIFUNGAL: A REVIEW

*Vijay Patel and Deepak Ktiyar

ABSTRACT

Due to host toxicity, resistance, and side effects, the effectiveness of existing antifungal treatments for invasive fungal infections is declining, which presents a serious problem in modern medicine. These infections have drastically increased in recent decades, and their fatality rates have remained high. New resistance patterns, such as concurrent resistance to many antifungal classes, are escalating this problem. Recent developments in our knowledge of the processes behind fungal virulence and resistance have revealed possible new targets for antifungal treatments. To find new antifungal treatments, Techniques such as repurposing of already authorised drugs, high throughput evaluations of natural substances, and chemical genomics-based screens are being researched. The present pipeline is still lacking, with just a few numbers of promising compounds exhibiting unique mechanisms of early stages of clinical development activity, despite the pressing need for effective therapies.

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