EFFICACY AND PATEINT-CENTERED OUTCOMES OF ANTIASTHMATIC ORODISPERSIBLE TABLETS IN ACUTE ASTHMA EXACERBATION

Krutika Mandloi, Kratika Khadsondni, Aman Kumar, Tushar Sonare, Dr. Akash Yadav*, Dr. Dinesh Kumar Jain

ABSTRACT

Objective: The main objective of this study is to formulate salbutamol sulphate as mouth-dissolving tablets by using lepidium sativum mucilage as a natural superdisintegrant for rapid action to relieve. Methods: The formulation of the salbutamol sulphate using different concentrations of lepidium sativum mucilage (2%-8%, w/w) as a natural superdisintegrant and compared with the semisynthetic and synthetic superdisintegrants that are already present, like crospovidone and croscarmellose sodium. An attempt was made to extract Lepidium sativum and evaluate its various physiochemical characterizations. Results: The formulated tablets are evaluated for different physical tests like weight variation, hardness, friability, and disintegration time, and the results are shown with the limits. The in vitro release of all the formulations is studied and assessed that all are released by first-order kinetics. From all the formulations, F4, which contains lepidium sativum with an 8% concentration, performed at the least disintegration time of 18 seconds, resulting in a higher in vitro release rate of 95% at the end of 30 minutes. Hence, the f4 batch is considered an optimized batch. This study proposed that the natural superdisintegrants performance has better disintegrating properties than the widely used synthetic superdisintegrants in the formulation of the mouth-dissolving tablets. Conclusion: As per the results, the Lepidium sativum mucilage acts as a natural super disintegrating agent and has better disintegrating properties than the synthetic super disintegrants.

Keywords: Mouth dissolving tablet, Salbutamol Sulphate, Lepidium sativum, Crospovidone, croscarmellose sodium.