BUCCAL TABLETS A COMPREHENSIVE REVIEW

V. T. Iswariya* and A. Hari Om Prakash Rao

ABSTRACT

Buccal route is excellent for the systemic delivery, there by rendering great bioavailability. Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. Through this route it is possible to realize mucosal (local effect) and transmucosal (systemic effect) drug administration. In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrier to reach the systemic circulation. The present study involved is buccal tablets of irbesartan an anti-hypertensive drug which has low solubility, so, by using different mucoadhesive polymers such as Carbopol 934, Sodium alginate and HPMC K4M in combination The effective physiological removal mechanisms of the oral cavity that take the formulation away from the absorption site are the other obstacles that have to be considered. The formulations were developed with different concentration of mucoadhesive polymers in each formulation. The formulated buccal tablets were tested for surface pH, in vitro drug release and moisture absorption.

Keywords: Buccal Tablets, Irbesartan, Formulation design, Mucoadhesive polymers.