LABORATORY EFFECTS OF ORAL TREATMENT WITH VITAMIN D IN PATIENTS WITH PLAQUE PSORIASIS

*Dr. Roula Baddour, Dr. Yousef Zrek and Dr. Marah Aldali

ABSTRACT

Background: Psoriasis is a chronic T-cell-mediated inflammatory skin disease. Recently, many studies have reported an important role for vitamin D in the pathogenesis and treatment of the disease. Objective: To study the laboratory effects of oral vitamin D therapy in patients with plaque psoriasis. Materials and Techniques: The study included 50 patients who have been given oral vitamin D at a dose of 60,000 IU every two weeks for six months. The level of vitamin D in the serum, phosphorus, parathyroid hormone, and inflammatory reaction protein has been measured as well as other analyses. Results: Giving oral vitamin D to psoriasis patients leads to an increase in the level of the vitamin D in the serum after three and six months (average vitamin D /17.2±5.3/. After three and six months /24.15±4.5/ and /40.1±10.8/, respectively. Moreover, the results also showed an inverse relationship between high vitamin D and low PTH. Other Test results were similar. No significant side effects were recorded. Conclusion: Giving oral vitamin D in psoriasis increases the level of vitamin D in the serum without having any significant effect on other laboratory tests.

Keywords: Psoriasis, serum vitamin D level.