THE EFFECTS OF NATURAL VS SYNTHETIC SUPERDISINTEGRANTS ON ODT DISSOLUTION PROFILES AND DISINTEGRATION TIMES

Aman Kumar, Tushar Sonare, Krutika Mandloi, Kratika Khadsondni, Dr. Akash Yadav*, Dr. Dinesh Kumar Jain

ABSTRACT

The development of Orally Disintegrating Tablets (ODTs) for antihypertensive drugs presents a significant
opportunity to improve patient adherence, particularly for those with difficulty swallowing conventional tablets.
This study explore s the influence of natural versus synthetic superdisintegrants on the disintegration time and
dissolution profile of ODTs formulated with hydrochlorothiazide. The excipients employed include locust bean
gum as natural superdisintegrants, cross povidone as a synthetic superdisintegrant, banana Starch as a binder, corn
starch and talc as glidants, magnesium stearate as a lubricant, microcrystalline cellulose (MCC) as a filler, and
aspartame as a sweetener. Additionally, polyethylene glycol 4000 (PEG 4000) is incorporated as a solubility
enhancer via solid dispersion techniques. The formulation process uses a Box Behnken Design (BBD) to evaluate
the effect of locust bean gum, and Cross povidone concentrations on tablet properties, including disintegration
time, dissolution rate, hardness, and friability. The optimized formulation demonstrates rapid disintegration within
30 seconds, enhanced dissolution rates, and improved bioavailability of hydrochlorothiazide, attributed to the
solubility enhancing properties o f PEG 4000. These findings highlight the potential of natural and synthetic
superdisintegrants with solid phase dispersion methods to enhance the therapeutic efficacy of ODTs, offering a
promising approach to improving the treatment of hypertension.

Keywords: Hypertension, Orally Disintegrating Tablets, Hydrochlorothiazide, Superdisintegrants, Box Behnken Design, Dissolution efficiency, Solubility Enhancement.