THE RELATIONSHIP BETWEEN DIFFERENT PSORIASIS TYPES AND THYROID DYSFUNCTIONS

Abdallah Omar Ahmed*, Jamal Khaddam and Faisal Redwan

ABSTRACT

Background: Psoriasis is considered a common inflammatory and proliferative condition of the skin. Association between psoriasis and thyroid disorders have been suggested, but the prevalence of disorders vary widely. Aim: The purpose of this study was to evaluate the levels of thyroid hormones in psoriasis patients, as well as the association of thyroid dysfunction with severity of disease and demographic characteristics of patients. Patients and Methods: This was an analytic study (case-control) involved 45 patients with a diagnosis of psoriasis referred to clinic of dermatology, Lattakia University Hospital during one-year period (2023-2024) who were compared with a group of healthy individuals regarding of thyroid gland function. Results: There were no significant differences between two groups regarding of age (p:0.7) and gender(p:0.5). Plaque psoriasis represented the most frequent type in 31 cases (68.9%) with presence a family history of psoriasis in 29 cases (64.4%). Mean values of thyroid hormones were significantly lower in patients compared to control; thyroid stimulating hormone TSH (1.6±0.7 vs. 3.35±0.4,p=0.0001), thyroxin T4(0.86±0.2 vs. 1.38±0.2,p=0.0001) and triiodothyronine T3 (3.12±0.4 vs. 4.03±0.6,p=0.0001). Mean values of thyroid hormones were decreased significantly with increasing Psoriasis Area Severity Index PASI (severe versus mild); TSH (1.26±0.8 vs. 2.11±0.1, p=0.03), T4(0.64±0.1 vs. 0.98±0.4,p=0.04) and T3 (2.16±1.2 vs. 3.07±1.9,p=0.04). In addition to, there were no significant between thyroid dysfunction and the following variables; age, sex, duration of disease and the type of psoriasis, p>0.05). Conclusion: The current study revealed that thyroid dysfunction is prevalent in patients with psoriasis especially in severe cases, so that early detection is considered crucial to improve final outcome of patients.

Keywords: Psoriasis, PASI, thyroid, hormones, Syria.