FORMULATION AND EVALUATION OF ANTIEPILEPTIC DRUG-LOADED NANOSPHERES: A COMPREHENSIVE OVERVIEW

Karthik V.*, Venkatesh, Salman M. and Hanumanthachar Joshi

ABSTRACT

Epilepsy is a prevalent neurological disorder affecting over 50 million people globally, with approximately 5 million new cases diagnosed each year. It is characterized by aberrant brain activity leading to seizures, often resulting from sudden and excessive neuronal discharges. Despite its widespread impact, epilepsy remains a complex condition with diverse underlying causes and manifestations, affecting individuals across all age groups, particularly Pediatrics and Geriatrics. The delivery of therapeutic agents to specific sites in the brain poses significant challenges in treating epilepsy. However, the emergence of nanotechnology offers promising solutions by enhancing drug performance through nano-sized formulations. Nanospheres, a subset of polymeric nanoparticles with sizes ranging from 10 to 200 nm, are particularly advantageous due to their ability to encapsulate a variety of drugs, enzymes, and genes, and their long circulation time. These nanospheres enable targeted drug delivery, which is crucial for effectively managing epilepsy. Overall, nanotechnology holds significant promise for improving the treatment of epilepsy by enhancing drug delivery and targeting capabilities.

Keywords: Nanospheres, Drug targeting, Drug delivery, epilepsy.