METRONIDAZOLE-EXCIPIENT COMPATIBILITY STUDIES FOR MEDICATED CHEWING GUM DELIVERY SYSTEMS DEVELOPMENT

Mahmoud Mahyoob Alburyhi*, Maged Alwan Noman and Abdalwali Ahmed Saif

ABSTRACT

Metronidazole is an antibiotic used to treat various bacterial and parasitic infections. Metronidazole has been proved to be efficacious in treating: acute ulcerative gingivitis, pericoronitis, certain infections, some cases of osteomyelitis and infected socket. The drug may be of use in cases of chronic progressive periodontitis where anaerobes are implicated as pathogens. The main objective of the present study was to the preformulation studies were performed to know the physico-chemical and mechanical properties of Metronidazole for formulation development of Metronidazole Medicated Chewing Gum (MCG). The drug-excipient compatibility studies were conducted to characterize the drug Metronidazole Medicated Chewing Gum (MCG): A Modern Oral Drug Delivery System. Preformulation, formulation and evaluation of Metronidazole to avoid problems associated with conventional delivery system such as limited permeation, low release and bioavailability and also to improve bioavailability and providing more effective and convenient treatment methods. The compatibility was assessed by, FTIR spectroscopy, and melting point apparatus, precompression parameters and powder flow properties. Results showed that physical mixtures of Metronidazole and various excipients such as Mannitol, MCC, CMC, Acacia gum, Xanthan gum, etc, were evaluated for preformulation studies parameters. It was concluded that the drug Metronidazole was found to be compatible with various excipients which were selected for the formulation development of the Metronidazole MCG Delivery systems. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the ADDS (Advanced Drug Delivery Systems) product development process.

Keywords: Metronidazole, Compatibility, Medicated Chewing Gum, Development, Preformulation, MCG Delivery systems.