MICROWAVE ASSISTED SYNTHESIS AND ANTI INFLAMMATORY ACTIVITY OF SCHIFF BASE COMPLEXES DERIVED FROM META CHLORO ANILINE AND SALICYLALDEHYDE

Y. Pradeep Kumar, T. S. Mohamed Saleem and Konda Ravi Kumar*

ABSTRACT

The ligand, (2-((3-chlorophenylamino)methyl)Phenol) was synthesized by microwave method and used for the preparation of Zn (II),Co (II),Fe (II),Cu (II),Mg(II) complexes these were identified by melting point ,TLC and characterised using infrared and UV Visible spectroscopy. The infrared spectra data of this ligand and its metal complexes show that the ligand is a bidentate molecule which coordinated to the metal ions through the azomethine nitrogen and to the adjacent alkenic carbon atom. Anti inflammatory activity was conducted for all synthesized compounds by using Inhibition of albumin denaturation method (In vitro method) diclofenac sodium as reference standard.

Keywords: Ligand, metal, synthesis, Schiff base, Diclofenac.