INFLUENCE OF SITAGLIPTIN ON PHARMACOKINETICS OF RALTEGRAVIR IN RATS

Dr. T. Lakshmi*

ABSTRACT

As antiretroviral therapy becomes increasingly accessible, the associated improvements in the health, quality of life and survival of patients. HIV infection and treatment has been associated with the development of insulin resistance, glucose intolerance and diabetes. The aim of the present study was to evaluate the effect of sitagliptin (antidiabetic drug) on pharmacokinetics of raltegravir (antiHIV drug) in rats. The pharmacokinetic parameters like t1/2, AUC, Clearance, Tmax and Cmax of raltegravir with and without combination of sitagliptin treatment was determined. The plasma concentration-time profiles of raltegravir following single dose and multiple dose treatment of sitagliptin were found to be dissimilar. There was change in the pharmacokinetic parameters in presence of sitagliptin indicates the significant (p>0.05) pharmacokinetic interaction.

Keywords: Raltegravir, sitagliptin, pharmacokinetics.