HEPATOPROTECTIVE POTENTIAL OF METHANOLIC LEAF EXTRACT OF TRICHURIELLA MONSONIAE AGAINST PARACETAMOL INDUCED HEPATOTOXICITY IN RATS

*A. Rajani and A. Jaswanth

ABSTRACT

The present study, the methanol extract of Trichuriella monsoniae leaf was evaluated for their protective effects on paracetamol-induced liver damage in Wistar albino rats. Serum biochemical parameters viz. aspartate aminotransferase (AST), alanine transaminases (ALT), alkaline phosphatase (ALP), total protein (TP), bilirubin, cholesterol, albumin (ALB), lactae dehydrogenase (LDH), triglycerides (TG); and liver biochemical parameters such as reduced glutathione (GSH) content and catalase (CAT) and superoxide dismutase (SOD) activities were evaluated. Paracetamol (500mg/kg) induces hepatotoxicity and enhances the ALT, AST, ALP, liver weight and reduces total proteins. Treatment with Methanolic leaf extract of Trichuriella monsoniae (400 mg/kg) has brought back the altered levels of biochemical markers significantly to the near normal levels. The results were supported by histopathological studies of liver tissue. Phytochemical analysis of Trichuriella monsoniae indicated the presence of alkaloids, phenolics, saponins, flavonoids and polysaccharides. The study concluded that, the hepatoprotective potential may be attributed to the presence of flavonoids.

Keywords: Trichuriella monsoniae, Biochemical markers, Hepatoprotective & Hepatotoxicity, Paracetamol, Methanolic leaf extract.