NEPHROPROTECTIVE ROLE OF NEERI-KFT (A POLYHERBAL FORMULATION) AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN EXPERIMENTAL RAT MODEL: A PRE-CLINICAL STUDY

Manish Kr. Tiwari, Sanchit Sharma, Ikshit Sharma, Parveen Kr. Goyal, Santosh Kr. Verma, Amit Barwal, Anil Kr. Sharma*

ABSTRACT

The present manuscript is mainly focused to experimentally elucidate the nephroprotective potential of Neeri-KFT (a polyherbal formulation for renal disorders hereinafter mentioned as NR-KFT) against aminoglycoside antibiotic Gentamicin (80mg/kg, i.p.) induced nephrotoxicity in albino Wistar rats. The nephroprotective potential of NR-KFT was also compared with ethanolic extract of Boerhaavia diffusa (Family: Nyctaginaceae), which is a vital constituent of NR-KFT and also individually used in renal disorders, to elucidate the synergism or additive effect of multiple herbal drugs present in NR-KFT. Since, many researchers mainly focused on antioxidants for nephroprotective potential therefore to elucidate that NR-KFT is not merely antioxidant, but exhibit nephroprotective potential, it was also compared with antioxidant Vitamin E. The experimental findings proved that NR-KFT possessed significant nephroprotective potential along with antioxidant activity; and the different herbal constituents present also potentiated the nephroprotective effect to produce wholesome better effect of correcting altered renal architecture and improving renal physiology. Conclusively, the NR-KFT showed significant nephroprotective potential in these pre-clinical studies.

Keywords: Neeri-KFT, Nephrotoxicity, Gentamicin, Nephroprotective, Boerhaavia diffusa, Vitamin E.