MULTICOMPONENT MW ASSISTED SYNTHESIS OF 3-THIOXO-1,2,4-TRIAZIN-5-ONE DERIVATIVES AS PROMISING AGENT IN FIBROSIS TREATMENT

Savita Dhongade-Desai*, Sandeep Kenawade, Uttam Chougale and Uttam Khot

ABSTRACT

Triazine is a six member heterocyclic ring system having three nitrogen atoms. Many 1,2,4- triazine derivatives involve in several biological processes and serve as medicinally interesting compounds as they show a broad spectrum of antimicrobial activity such as anti-protozoals, anti-cancer, estrogen receptor modulator,anti-virals, and anti-malerials. Keeping in view the high pharmacological importance we report here a synthesis of several 4-substituted-3-thioxo-1,2,4-triazin-5-one derivatives using environmentally benign protocol where, neat reactants are subjected to microwave irradiation. The synthesized compounds were characterized by IR, 1HNMR, 13CNMR, mass spectral data and elemental analysis. The confirmed structures were subjected to PASS for their probabilities of being biologically active. Biological prediction study of these derivatives was done using computer programme PASS to find out the most active molecules. Short reaction time, good yield (69-85%), simple workup procedure are the remarkable features of this protocol.

Keywords: 3-thioxo-1,2,4-triazin-5-one, Biological Prediction Study, Microwave Irradiation.