A REVIEW ON CARDIOVASCULAR RISK OF SULFONYL UREAS IN DIABETIC PATIENTS

B. Praveena, K. Mohan Teja, J. N. Suresh Kumar and V. Satyanarayana* 

ABSTRACT

Diabetes is a chronic metabolic disorder. Untreated diabetes mellitus may cause many microvascular complications. Better control of diabetes mellitus reduces microvascular complications, but has limited effect on macrovascular complications including cardiovascular mortality. A spite of controversial reports has shown that some new oral antidiabetic drugs may paradoxically increase cardiovascular and mortality. Some sulfonyl ureas increase cardiovascular risks presumably by preventing protective ischemic cardiac preconditioning. We review here publish data on cardiac safety of currently available oral antidiabetic drugs.

Keywords: sulfonyl ureas, cardiovascular risk, metabolic disorder, oral antidiabetic drugs.