COMPARATIVE EFFICACY OF ROSUVASTATIN AND ATORVASTATIN IN PATIENTS WITH CORONARY ARTERY DISEASE

Akhilendran R., Hima Mahesh, Fahida Farook, Swathi M., Pradeep P., Veena Vijayan G.*

ABSTRACT

The objective of study was to compare the lipid lowering efficacy of Atorvastatin and Rosuvastatin in Coronary Artery Disease patients. In this study we analyzed data of 130 patients of IP and OP department of tertiary care hospital in south Kerala over a period of 6 months. Patients above 18yrs of age presenting with coronary artery disease and dyslipidemia were included in this study. The lipid profile values were noted and rechecked at an interval of 6 weeks to compare the efficacy of Atorvastatin and Rosuvastatin. Atorvastatin 20mg was comparable to Rosuvastatin 10mg. According to the doseresponse analysis, mean differences between the LDL, Triglyceride and Total cholesterol dose responses of Rosuvastatin 10 to 40mg versus Atorvastatin 10 to 40mg were significant. HDL C increasing effect of Rosuvastatin at doses of 10, 20, 40mg were found to be comparatively higher than Atorvastatin at similar doses after 6 weeks of treatment. Across dose ranges HDL C increasing effect was found to be rising with dose with both statins. The best LDL C, Triglyceride and Total Cholesterol reductions with Rosuvastatin were obtained at dose of 40mg. The study concluded with the findings that Rosuvastatin was found to be more efficacious in lowering LDL level compared to Atorvastatin.

Keywords: Comparative study, Atorvastatin, Rosuvastatin, Dyslipidemia.