FORMULATION AND EVALUATION OF ESOMEPRAZOLE MUCOADHESIVE BUCCAL TABLETS

K. Nagarani*, Dr. J. Krishnaveni, Dr. Harish Kommera, Lalan Kumar Sinha, A. Hari Om Prakash Rao

ABSTRACT

Esomeprazole pellets containing mucoadhesive tablets were developed by direct punch method. Three mucoadhesive polymers namely hydroxypropylemethylcellulose K 100 M, Carbopol 934, HPMC K 15 M, were used for preparation of tablets which intended for prolong action may be due to the attachment with intestinal mucosa for relief from active duodenal ulcer. The prepared tablets were evaluated for different physical parameters and dissolution study were performed in two dissolution mediums like pH 6.8 and pH 7.4 phosphate buffer solution. The release mechanism of all formulation was diffusion controlled confirmed from Higuchi’s plot. Thus, the present study concluded that, carbopol-934P containing mucoadhesive tablets of omeprazole pellets can be used for local action in the ulcer disease.

Keywords: Mucoadhesion, esomeprazole, direct compression, ulcer.