“THERMODYNAMIC STUDY OF SUBSTITUTED THIOCARBAMIDO-NAPHTHOLS AT DIFFERENT CONCENTRATIONS AND DIFFERENT TEMPERATURES IN MIXED SOLVENT MEDIA”

Dipak T. Tayade and Ajay B. Wadekar

ABSTRACT

Conductivity play vital role in drug diffusion. Thermodynamic parameters affected by substituent’s of drug. Thus recently in laboratory, conductometrically have been investigated thermodynamic parameters of 5-Phenylthiocarbamido-1-naphthol [PTCN] or L2 and 5-p-Tolyl -thiocarbamido-1-naphthol [p-MPTCN] or L4 have been studied at different concentrations in 80% ethanol-water mixture at different temperatures. This work highlights investigation of G, K and µ values. The thermodynamic parameters viz. ΔH, ΔS and ∆G for ion pair formation determine from the value of ion association constant at 298K and 303K. This investigation provided valuable information regarding to solute-solvents, solute–solute and solvent-solvent interaction, effect of various substituent’s of drugs and effect of dilution from conductometric measurements of 5-Phenyl -thiocarbamido-1-nahthol and 5-p-Tolylthiocarbamido-1-naphthol.

Keywords: Thermodynamic parameters, 5-Phenylthiocarbamido-1-nahthol [PTCN] and 5-p-Tolylthiocarbamido-1-naphthol or L4 [p-MPTCN].