“THERMODYNAMIC STUDY OF SUBSTITUTED THIOCARBAMIDO-NAPHTHOLS AT DIFFERENT CONCENTRATIONS AND DIFFERENT TEMPERATURES IN MIXED SOLVENT MEDIA”

Dipak T. Tayade and Ajay B. Wadekar*

ABSTRACT

Conductivity play vital role in drug diffusion. Thermodynamic parameters affected by substituent’s of drug. Thus recently in laboratory, conductometrically have been investigated thermodynamic parameters of 5-Phenylthiocarbamido-1-naphthol [PTCN] or L2 and 5-p-Tolyl -thiocarbamido-1-naphthol [p-MPTCN] or L4 have been studied at different concentrations in 80% ethanol-water mixture at different temperatures. This work highlights investigation of G, K and µ values. The thermodynamic parameters viz. ΔH, ΔS and ∆G for ion pair formation determine from the value of ion association constant at 298K and 303K. This investigation provided valuable information regarding to solute-solvents, solute–solute and solvent-solvent interaction, effect of various substituent’s of drugs and effect of dilution from conductometric measurements of 5-Phenyl -thiocarbamido-1-nahthol and 5-p-Tolylthiocarbamido-1-naphthol.

Keywords: Thermodynamic parameters, 5-Phenylthiocarbamido-1-nahthol [PTCN] and 5-p-Tolylthiocarbamido-1-naphthol or L4 [p-MPTCN].