HORMONAL PROFILE IN EARLY MENOPAUSE

Eltayeb Tayrab*, Rasha Musa and Zeinab Abdalla

ABSTRACT

Early cessation of the cycle in the reproductive age is harsh for women. The aim of this study was to evaluate the hormonal profile in infertile Sudanese women complaining of premenopausal amenorrhea, including serum luteinizing hormone (LH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), prolactin and estradiol (E2). This case control- cross sectional study was done in the 5 clinics of infertility in tertiary care hospitals in Khartoum-Sudan, from: May 2012 to December 2014. The study included 323 infertile premenopausal amenorrheic women and 198 ages matched women with proven fertility as control. ELISA method was used to measure serum levels of FSH, LH, TSH, prolactin and E2. Data was analyzed by IBM, SPSS version 20. The mean of the prolactin in the amenorrheic women was (121.5±1 265.12)ng/ml versus (15.09± 6.07)ng/ml in the control group; with P. value (0.000), FSH (50.33 ± 34.04) IU/ml versus (8.71 ± 31.29) IU/ml; with P.value (0.000), LH (34.89± 22.71) IU/ml versus (6.27± 2.55) IU/ml; with P.value (0.000), TSH (1.75± 2.02)IU/ml) versus (1.27± 0.76) IU/ml; with P.value (0.004) and E2 (40.16± 34.30)pg/ml versus (50.68± 16.74)pg/ml ;with P value (0.029). The prevalence of secondary amenorrhea among the study group was 315 (97.5%). In premenopausal amenorrheic Sudanese; secondary amenorrheic is most common. Serum prolactin, FSH, LH, and TSH significantly increase; while estradiol significantly decreases.

Keywords: Premenopause, amenorrhea, hormones, serum, Sudan.