COMPARISON AND CORELATION OF THE PERIODIC ACID SCHIFF STAINING INTENSITY OF ORAL EXFOLIATIVE CELLS WITH FASTING BLOOD SUGAR IN TYPE 2 DIABETIC PATIENTS

Dr.Rahul Agrawal, Dr. Adit, *Dr. Kanupriya Gupta and Dr. Naresh Kumar

ABSTRACT

Objectives: Type-2 Diabetes Mellitus (DM) has considerable prevalence in India. A non-invasive diagnostic tool will be more appropriate in conditions like DM. In present study we are intend to find glycogen accumulation (if any) in buccal mucosa exfoliated cells of type-2 DM patients when compare to non-diabetic healthy individuals, and establish its diagnostic role. Methods: In present study 36 known DM patients with at least 1 year history (Case group) and 36 healthy, age and gender matched subjects (control group) were included. Patients with any other systemic disease were excluded from the study. Buccal mucosa exfoliate cytology smears were prepared from all 72 subjects and stained with PAS stains. Number of PAS positive cells per 50 cells in the smear was calculated. The data was tabulated and statistically analysed using chi square test, student‘t’ test, Karl pearson’s correlation coefficient and significance (2tailed) test. Results: Statistically significant difference was found in number of PAS positive cells in exfoliative cytology of DM patient group when compared with control group. Conclusion: glycogen accumulation in exfoliated buccal mucosa cells of type-2 DM patients can have diagnostic value which needs to be explored further.

Keywords: Exfoliative cytology, diabetes mellitus, glycogen.