CORRELATION OF FINE NEEDLE ASPIRATION CYTOLOGY WITH HISTOPATHOLOGICAL DIAGNOSIS IN THYROID LESIONS

*Gupta Mohan Lal and Talreja Khushbu

ABSTRACT

Introduction: Thyroid lesions are easily accessible for Fine needle aspiration cytology (FNAC). FNAC is very safe and simple rapid process to rule out malignancies. Since majority of thyroid lesions are benign and require simple excision of the tumor, FNAC may be a cost effective method for the diagnosis of thyroid lesions. The aim of present study is to evaluate sensitivity, specificity and predictive value of FNAC in Thyroid lesions. Material and method: The present study is retrospective analysis of FNAC of 120 patients who were operated for biopsy and Histopathological diagnosis. Result and conclusion: Patients ranging from 20 to 70 years show that majority of patients fall between 21 to 30 years and majority of patients were female. Male to female ratio was 1:4. Histopathological diagnosis in majority of cases was follicular adenoma followed by colloid adenoma. By FNAC most of the patients were diagnosed as follicular adenoma followed by Colloid adenoma and Hashimoto’s / lymphocytic thyroiditis. Papillary carcinoma and follicular carcinoma was suspected in 8.33% and 5.0% patients respectively. Correlating the FNAC diagnosis with Histopathology reveals accuracy in follicular adenoma 89.2%, in colloid adenoma 87%, in papillary carcinoma 80% and in follicular carcinoma 83.3%. Overall concordance was found to be 86.66%. Sensitivity of FNAC calculated was 76.7% and Specificity was 97.08% hence positive predictive value was 81.25% and negative predictive value was 96.15%. FNAC is a very reliable, rapid and accurate procedure to differentiate a malignant lesion from a benign.

Keywords: Thyroid lesions, FNAC, Sensitivity, specificity, predictive value.