AMELIORATIVE EFFECT OF ACONITUM HETEROPHYLLUM (WALL EX ROYLE) ON, ERYTHROCYTE ANTIOXIDANTS AND LIPID PEROXIDATION IN STZ- INDUCED DIABETIC RATS

Tanveer Ahmad Rah, S. Hemalatha*, C. Elanchezhiyan and G. Archunan

ABSTRACT

The present study was carried out to evaluate the beneficial effects of Aconitum heterophyllum (AH) on altered erythrocyte lipid peroxides and antioxidants in streptozotocin induced diabetic rats. Diabetes mellitus was induced in adult male albino wistar rats by a single intraperitoneal injection of streptozotocin (40 mg/kg of body weight). The streptozotocin induced diabetic rats were treated with Aconitum heterophyllum extract 200 mg/kg b.w for 28 days. The enzymatic superoxide dismutase (SOD), Catalase (CAT) and glutathione peroxidase (Gpx) and non-enzymatic antioxidants Vitamin C, Vitamin E and Reduced Glutathione antioxidant activity significantly decreased and simultaneously lipid peroxidation markers like thiobarbituric acid reactive substances (TBARS) and hydroperoxides (LOOH) significantly was increased in erythrocytes of diabetic rats. Administration of Aconitum heterophyllum (200mg/kg bw) and glibenclamide reverted these parameters towards normalcy when compared with untreated diabetic rats. From the present study, it is evident that, Aconitum heterophyllum extract possesses significant, antioxidant and antilipidperoxidation properties without any toxic effects.

Keywords: Erythrocytes, Aconitum heterophyllum, antioxidants.