ANALGESIC AND ANTI-INFLAMMATORY STUDIES OF METHANOL EXTRACT OF I. FRUTESCENS ON EXPERIMENTAL MICE

A. K. Azad1*, Ohidul Islam1, M. Anwarul Islam, M. Saifuddin, Manirul Islam, M. Khairuzzaman, Abdullahil Kafi, Imran Hasan, Shoumen Lasker and Irfan-Ur-Rahaman

ABSTRACT

Almost all analgesic and anti-inflammatory drugs cause hyperacidity and peptic ulcer. To find the new source of drug, present study was carried out to evaluate analgesic and anti-inflammatory effects of methanol extract of I. frutescens. I. frutescens showed significant analgesic effects (p<0.001) on acetic acid induced writhing of mice compare to control group where diclofenac sodium was used as a reference standard. I. frutescens decreased the carrageenan induced paw edema notably (*p<0.05, **p<0.01 and ***P-value<0.001) compare to control group in which standard was diclofenac sodium. phytochemical screening indicated the presence of Glycoside, Flavonoid, Saponin and Steroid. Analgesic and anti-inflammatory effects may be due to the presence of Glycoside, Flavonoid but further study needed.

Keywords: Analgesic, anti-inflammatory, acetic acid, carrageenan, I. frutescens.