EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF PHOLIDOTA ARTICULATA EXTRACTS

Darshan Singh*, S. C. Sati and M. D. Sati

ABSTRACT

Evaluation of anti-inflammatory property of Pholidota articulata whole plant with preliminary phytochemical profile of the extracts has been carried out in this part of work. The dried plant material was packed in Soxhlet apparatus and extracted successively with pet-ether to de-fat the drug, petroleum-ether was removed from the powdered defatted drug, which was then extracted with chloroform and methanol as increasing polarity. All the extracts were screened for anti-inflammatory activity using carrageenan induced paw edema. The toxicity and phytochemical screening were done using standard procedure. Alkaloids, flavonoids, phenolic compounds, glycosides carbohydrates, proteins, gums and amino acids have been determined by preliminary phytochemical tests. The acute toxicity study of various extracts of Pholidota articulata was conducted and dose of 3000 mg kg-1 body weight fixed for anti-inflammatory activity.

Keywords: Pholidota articulataOrchidaceae Anti-inflammatory activity, Indomethacin.