ARTIMISININ A SESQUITERPENE LACTONE WITH AN ENDOPEROXIDE BRIDGE IS TOXIC TO MALARIAL PARASITES.

Abdolhossein Rustaiyan*, Afsaneh Faridchehr and Mehdi Bakhtiyari

ABSTRACT

Each year there are 300-500 million cases of malaria resulting in over million deaths from the disease world-wide. Malaria is especially in acute sub-Sahara Africa, where official estimate that two children die from malaria every minute. Resistance of the malaria parasite to longstanding treatments is for new antimalarial therapies. Artemisinin and synthetic derivatives are the focus of intense efforts to develop new drugs against malaria.

Keywords: Artemisia annua, Sesquiterpene lactone, Anti- malarial effect, New anti-malarial candidate, Biosynthesis of Artemisinin.