PHYTOCHEMICAL SCREENING, FORMULATION AND EVALUATION OF WOUND HEALING ACTIVITY OF ROOT EXTRACT OF ERIOLAENA HOOKERIANA WT.ARN. OINTMENT ON RATS

K. Kishore Kumar*, K. Gnananath, S. Sujatha, B. Aswani and J. Sivajyothi

ABSTRACT

Objective: Formulation and evaluation of herbal ointment of Eriolaena hookeriana Wt. & Arn. root extract for wound healing potential by excision and incision models on male wistar rats. Methods: Wound healing activity was studied in two types of model in rat’s viz. excision and incision. In case of the excision wound model parameters like wound contraction and period of epithelialization were studied while in incision wound model, tensile strength of the wound was measured. Results: In both the models treatment of wound with ointment containing 5% (w/w) extracts showed good wound healing activity (p<0.01) in comparison with control. Conclusion: The results of present study suggested that extracts of Eriolaena hookeriana Wt. & Arn. Possess potent wound healing activity justifying its use in folklore.

Keywords: Eriolaena hookeriana, Excision method, Incision method, Tensiometer.