COMPARATIVE STUDY OF METABOLIC SYNDROME MARKERS IN PSORIATIC PATIENTS AND NON PSORIATIC CONTROLS

Manikya Latha S.* and V. V. V. Satyanarayana

ABSTRACT

Aim and Objective: Psoriasis is a chronic inflammatory skin disorder affecting 1-3% of the population. Psoriasis may act as an external indicator of underlying immune and metabolic dysregulation. The present study aims to know the prevalence of metabolic syndrome in Psoriatic patients and also prevalence of individual components of syndrome. Materials and Methods: 100 patients of psoriasis confirmed by histopathological examination, aged >25yrs. Age and sex matched controls were included in the study. severity of psoriasis was assessed according to Psoriasis Area and Severity Index[PASI] and body surface area[BSA]. Metabolic syndrome was diagnosed by the presence of at least 3 criteria of NCEP ATP III with Asian modification for waist circumference. The markers of metabolic syndrome in psoriatic patients and nonpsoriatic controls which includes Abdominal obesity, Blood pressure Fasting blood glucose level was measured using a glucose oxidase method. Serum triglyceride level, Serum HDL level are measured with enzymatic procedures. Results: In the present study prevalence of metabolic syndrome in psoriatic patients was higher than in controls [42.0% vs 22.0%] and association between psoriasis and metabolic syndrome was statistically significant. Prevalence of abnormal fasting blood sugars was more in psoriasis patients than controls [56.0% vs 24%]. HDL levels are low in psoriatic patients than in controls [58% vs 32%]. Serum triglycerides levels are higher in Psoriatic patients than in controls(41.0% vs 35%). Abnormal blood pressure was more in psoriatic patients than in controls [37% vs 12%]. Central obesity was more in psoriatic patients than in controls [42% vs 18%]. Conclusion: Our study showed higher prevalence of metabolic syndrome in psoriatic patients than in controls. Prevalence of components of metabolic syndrome: diabetes, hypertention, obesity and dyslipidemia was higher in psoriatic patients than controls and significant statistical association was found with Central obesity, Hypertension, Fasting glucose and low HDL levels.

Keywords: diabetes, hypertention, obesity and dyslipidemia.