NEPHROPROTECTIVE ACTIVITY POTENTIAL OF ETHANOLIC HERBAL EXTRACT OF MELOTHRIA MADERASPATNA ON UNILATERAL URETERAL OBSTRUCTION INDUCED RAT MODEL.

Tharun Kumar.G*, Rahul Shukla, JSN Murthy, R. Raja Reddy

ABSTRACT

Melothria maderapatna is also called as Mukia maderapatna belongs to genus family Cucurbitaceae. It is a well known drug of siddha system of medicine. Recent research explored its antihyperglycemic and hypolipidemic potencial. In present study ethanolic extract of Melothria maderapatna was screened for Nephroprotective activity using Unilateral Ureteral Obstruction rat model. Parameters like change in body weight, cholesterol, creatinine, haemoglobin, levels of RBC, post operative survival rate, potassium, sodium, triglyceride, urea, and uric acid were estimated in experimental rats. The results showed that post operative survival rate of rats in the investigated novel method to be 100 percentages. Change in the body weight of ethanolic extract of Melothria maderapatna (EMME) treated groups-I and II was found to be 41gms and 36 gms respectively. The above values suggested that EMME treatment normalized the elevated body weight level in experimental rats. Furthermore EMME treatment normalized the decreased RBC level and also normalized the elevated hemoglobin, triglyceride, cholesterol, creatinine, urea, uric acid, Sodium and Potassium levels in experimental rats. The results indicate that Melothria maderapatna has strong nephroprotective activity. But, further scrutiny is essential for isolation and characterization of the active components, which can be employed to allay various human maladies.

Keywords: Melothria maderapatna, EMME, UUO.