TOXICITIES OF LEUNASE (L – ASPARAGINASE) ADMINISTRATION IN NORMAL HEALTHY RABBITS

Khwaja Ali Hasan, *Aziza Khanam and Sidra Rizwan

ABSTRACT

In the present study the effect of leunase (L-asparaginase) was investigated on healthy rabbits. The healthy rabbits were grouped into control and L-asparaginase treated animal. The L-asparaginase group rabbits had shown an increase in the level of serum glucose, amylase, urea and creatinine after 3 doses of 100 I.U. L-asparaginase on the 7th day of experiment, where as the level of serum protein in markedly decreased on 7th day of L-asparginase treatment. These observations suggest intervention strategies during the L-asparaginase treatment of acute lymphoblastic leukemic patients and the patients clinical monitoring for early diagnosis of these complication, is recommended.

Keywords: L-asparaginase, Amylase, Glucose, Urea, Creatinine.