EFFECTS OF AMLODIPINE AGAINST CISPLATIN-INDUCED NEPHROTOXICITY IN RABBITS

*Shihab Abdul-Rhman Shihab

ABSTRACT

Nephroprotective effect of amlodipine was investigated in rabbits with acute renal injury induced by a single i.p. injection of cisplatin (6.5 mg/kg). Amlodipine treatment (5mg/ kg/ day, orally) was applied for 7 consecutive days, starting 4 days before cisplatin administration. Amlodipine had highly significantly restored all of the studied parameters to near normal values with histopathology sections showing normal looking tubules with minimal necrosis. Amlodipine significantly compensated deficits in kidney tissue glutathione level, suppressed lipid peroxidation and decreased the elevations of serum tumor necrosis factor-alpha resulted from cisplatin administration. Also, histopathological renal tissue damage mediated by cisplatin as well as inflammatory cells infiltration was greatly ameliorated by amlodipine treatment. It was concluded that amlodipine represents a potential therapeutic option to protect against acute cisplatin nephrotoxicity commonly encountered in clinical practice.

Keywords: Amlodipine, Cisplatin, Nephrotoxicity.