EVALUATION THE EFFECT OF HYALURONIC ACID ON BONE HEALING PROCESS: AN EXPERIMENTAL STUDY IN THE RABBITS

*Ahmad Al Nashar, Issa Ahmad, Yasser Khedder and Osama Al-Khatib

ABSTRACT

This study was aimed to assess the effect of hyaluronic acid HA on bone healing in mandibular bone defect in the rabbits. Ten adult White male rabbits with a mean weight of 2.3 ± 0.42 kg were used as the animal model. Two cavities of 4mm diameter have been created in the lateral surface of the mandible. One of the cavities was filled with 1% HA gel soaked onto a pre-cut absorbable collagen sponge (test one), while the other hole was left for normal healing (control one). On the 4, 8 weeks, the rabbits have been sacrificed in equal numbers and defective regions have been extracted. At 8 weeks, histological analysis of specimens extracted from the cavities with HA showed large areas of woven bone contained osteocytes and covered by lining of osteoblasts .On the other hand small areas of woven bone and areas of osteoid bone were observed in the control cavities. Hyaluronic acid enhances the bone healing regeneration.

Keywords: Bone grafts, bone healing, hyaluronic acid.