A REVIEW ON CHROMATOGRAPHIC AND SPECTROPHOTOMETRIC ESTIMATION OF ESCITALOPRAM OXALATE AND ESZOPICLONE IN BULK AND IN DIFFERENT DOSAGE FORMS

Jignasha A. Panchal and Dr. Dilip G. Maheshwari*

ABSTRACT

Nowadays antidepressant drugs like selective serotonin reuptake inhibitors (SSRIs) represent the first choice in the treatment of moderate to severe depressive illness, various phobias, and personality disorders and non-benzodiazepine have a demonstrated efficacy in treating sleep disorders. This review includes most of the published analytical methods for estimation of Escitalopram oxalate and eszopiclone based on high-performance liquid chromatography coupled with UV, fluorescence and mass spectrometry detectors, capillary electrophoresis and gas chromatography with mass spectrometry detectors among others. Thus, this paper will help in the selection and development of proper analytical methodologies for estimation of SSRIs and non-benzodiazepine to achieve satisfactory results.

Keywords: Selective Serotonin Reuptake Inhibitors (SSRIS), Non – benzodiazepine, High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC).