EXPERIMENTAL EVALUATION OF ANTI-DIABETIC ACTIVITY AND ANTI HYPERLIPIDEMIC EVALUATION OF LEAF EXTRACTS OF SENNA ALATA IN ALLOXAN INDUCED DIABETIC RATS

Rama Swamy Nanna*, Archana Pamulaparthi, Vamshi Ramana Prathap, Mahitha Banala

ABSTRACT

Senna alata (Syn. Cassia alata) is an ethnomedicinal plant belonging to the family Fabaceae. A number of bioactive constituents which contribute to the medicinal properties are attributed to the species. The present study is aimed to evaluate the anti diabetic activity attributed to the species and also to evaluate the anti hyperlipidemic potential of the species using various standard experimental models available. Acute toxicity studies of aqueous leaf extracts of S. alata were performed upto a dose of 2500mg/kg bodyweight of rats and a dose of 200 mg/kg was selected for the present study. Aqueous leaf extracts of S. alata showed a significant (P<0.01) anti diabetic and anti hyperlipedimic potential in alloxan induced diabetic rats within 15 days of induction of diabetes and the antidiabetic potential of the species may be due to the presence of flavonoids.

Keywords: Senna alata, Alloxan induced diabetes, Anti Diabetic, Anti Hyperlipedemic.