EFFECT OF ALLIUM SATIVUM ESSENTIAL OIL ON THE GLYCEMIC CONTROL AND HYPERLIPIDEMIA IN TYPE 2 DIABETES MELLITUS SUBJECTS

Dr. Ali Naseer, Dr. Suhail Ahmed Almani*, Dr. Saad Abdul Quddus, Dr. Pir Maroof, Dr. Raza Naseer

ABSTRACT

Background: Allium sativum (AS) is used as herbal medicine since time immemorial. Allium sativum has shown anti- hyperglycemic, anti oxidant, anti cancer, and anti atherogenic activity. Objective: To analyze the glycemic improving potential and anti hyperlipidemia effects of Allium sativum essential oil (ASEO) in type 2 Diabetes mellitus (T2DM). Methods: The present interventional study was conducted at the Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad from December 2014 to May 2015. 100 diagnosed T2DM were enrolled for study protocol through non-probability sampling according to inclusion and exclusion criteria. Allium sativum essential oil (ASEO) was purchased from Pharmacy of the Isra university hospital. 13.5 mg of ASEO was given orally daily for six months. Blood samples were centrifuged to separate sera which were stored at -200C frozen. Blood glucose, glycated HbA1, and blood lipoproteins were measured by standard laboratory methods. Data was analyzed on SPSS 21.0 version using student t-test. P-value of ≤0.05 was taken statistically significant. Results: Diastolic blood pressure, random blood glucose, Glycated HbA1, total cholesterol, triglycerides, low and very low density lipoproteins showed significant reduction at third and sixth months compared to baseline (p < 0.001). While HDLc showed significant rise at third and sixth months (p < 0.001). Conclusion: The present study reports Allium sativum essential oil improves glycemic control and exerts anti-hyperlipidemic effect. A decrease in Diastolic blood pressure was also noted.

Keywords: Allium sativum Glycemic control Hyperlipidemia Diabetes mellitus.