GAMMA GLUTAMYL TRANSFERASE AS PREDICTIVE MARKER OF CAROTID INTIMA MEDIA THICKNESS IN TYPE 2 DIABETIC SUBJECTS

Dr. Farukhuddin*, Dr. Pooja Devi, Dr. Rabia Waseem Shaikh, Dr. Bilal Razaque Memon, Dr. Raheela Hassan, Dr. Shahzore Gul

ABSTRACT

Objective: To analyze the Gamma Glutamyl Transferase (ϒ-GT) as predictive marker of carotid intima media thickness (CIMT) in type 2 Diabetic subjects. Study Design: Case control study. Place & Duration: Department of Medicine -Liaquat University of Medical and Health Sciences Hospital from November 2015- August 2016. Subjects & Methods: A sample of 40 healthy controls and 45 type 2 diabetics was selected through non-probability (purposive) sampling by prior inclusion and exclusion criteria. Serum ϒ-GT was estimated by enzymatic colorimetric test. Carotid artery was examined with a 7.5-MHz linear-array transducer (Siemens Acuson x300) sonography. Data was analyzed using the SPSS 22.0 (USA) and Graph Pad Prism at 95% CI (P≤ 0.05). Results: Carotid intima media thickness (CIMT) in controls and cases was noted as 0.52± 0.07 and 0.75± 0.071 mm (P=0.0001). Significant ϒ-GT difference was noted between controls and cases i.e; 34.98± 5.47 and 42.71± 6.49 U/L (P=0.001). The ϒ-GT showed positive correlation with CIMT (r= 0.615, P=0.0001). The ϒ-GT significantly predicted the CIMT by simple linear regression model (F= 50.37, P= 00001, R2 = 0.378). Conclusion: The present study reports the serum ϒ-GT was increased in proportionate to CIMT. Serum ϒ-GT may be used as a non-invasive, inexpensive and easily available marker for atherosclerosis.

Keywords: Gamma glutamyl transferase Carotid intima media thickness Atherosclerosis Diabetes mellitus.