THE TREATMENT OF REFRACTORY NEPHROTIC SYNDROME IN CHILDREN

Liang Zhao and Hongzhu Lu.*

ABSTRACT

Idiopathic nephrotic syndrome is the commonest chronic kidney disease in children. Most of them are response to steroid treatment. However, about 20% patients are frequently relapse, steroid-dependent, or steroid-resistant nephrotic syndrome. These patients need immune-superresion agents, such as cyclophosphamide, calcineurin inhibitors, or mycophenolate motifol to maintain completely remission. Recently, rituximab used to treat refractory nephrotic syndrome as well. The selection of the drug should be carefully consider according to the disease condition and patients family.

Keywords: nephrotic syndrome; cyclophosphamide; calcineurin inhibitor; mycophenolate motifol; rituximab.