THE ROLE OF INFLAMMATORY MEDIATORS IN THE PATHOGENESIS OF PROGRESSIVE ANGINA PECTORIS COMBINED WITH DIABETES MELLITUS TYPE 2.

Kasimova M.S.*, Ismailova A.A., Shek A.B., Akhmedova Sh.S. and Khoshimov Sh.U.

ABSTRACT

The article presents the results of the study of serum levels of IL-6, TNF-α and C-reactive protein (CRP) in patients with unstable angina with the presence of diabetes mellitus type 2 (DM T2) and without it. Materials: We examined 34 patients with unstable angina of II B class in accordance with E. Braunwald (2000), all patients were divided into groups: the first group - was represented by 15 patients with unstable angina and DM T2, the second group was represented by 19 patients with unstable angina without DM T2. The average age of patients was 56,8 ± 1,7 years. The cytokines IL-6 and TNF-α were determined in serum by ELISA using kits produced by "Vector-Best" LTD (Novosibirsk, Russia) on the enzyme immunoassay analyzer «StatFax - 2100" (USA). Results: In patients with DM T2 have high values of CRP and fibrinogen, in excess of 2 (p<0,05) and 1,3 (p<0,01) times, than those without DM T2. When comparing the values of cytokines in patients with persons of the control group in patients with DM T2 was an increase in the level of IL - 6 to 12,3 times (p<0,01) and TNF-α in the 4,6 (p<0,05) times. In the group of patients with unstable angina and DM T2 revealed correlation between the IL-6 and TNF-α (r=0,84 p<0,001), TNF-α and fibrinogen (r=0,2), TNF-α and CRP (r=0,3; p<0,05), between the values of the level of fasting plasma glucose and HbA1c with CRP level (r=0,56; p<0,001 and r=0,31; p<0,05, respectively). Conclusions: In patients with unstable angina in combination with DM T2 a history of hypertension were more frequent (p<0.05) and the PICS (p<0.01). In patients with DM T2 the presence of inflammatory mediators values significantly higher relatively to patients with unstable angina without DM T2. Therefore, in patients with progressive angina absence of diabetes determines a more favorable course of the disease.

Keywords: unstable angina, diabetes mellitus type 2, cytokines, inflammation.