GASTRORETENTIVE: EXPANDING THE FIELD OF CONTROL DRUG DELIVERY

Ashutosh Badola* and Shailendra Kumar Sah

ABSTRACT

Besides all the novel approaches for the drug delivery, oral delivery approach is still one of the most desirable and preferred routes due to its ease of administration and high patient acceptability. Oral drug delivery depends on the various factors as gastric physiology, drug release, site of absorption and physiochemical properties of drugs. Design of the Gastroretentive dosage is done for the control of gastric retention time for the achievement of desired site specific effect and controlled release of drug over the desired time period. Gastroretentive facilitate the delivery of drug for local action to stomach and proximal part of the small intestine. These systems improve the bioavalability of drug with narrow absorptive window to the upper part of the GIT, unstable at intestinal pH, soluble in acidic pH providing them to reside in stomach for the appropriate time to get absorbed. In the recent year’s scientific and technological advancement have been made in the field of gastroretentive drug delivey system. Various approaches for the Gastro retention are floating system, bioadhesive system, swelling and expandable systems, magnetic system, high density system and raft forming system. Recently the controlled drug delivery is leading all other conventional delivery to reduce the frequency of dose and Gastro retentive is one of the safe and easy methods to achieve such effect by prolongation of the gastro retentive time. The need of this review paper was to focus the past and present approaches to achieve the desired gastric retention of the drugs for proper efficacy and therapy.

Keywords: Approaches for Gastric Retention, Floating System, Expandable System, Bioadhesive System, High Density System, Magnetic System.