ANTI-ULCER EFFECT OF ETHANOLIC EXTRACT OF ACACIA AURICULIFORMIS

Ramandeep Kaur* and Amanpreet Singh

ABSTRACT

The investigation was to evaluate gastroprotective effects of ethanolic extract of A. auriculiformis bark on pylorus induced and swimming induced gastric mucosal injuries in rats. Sixty rats were divided into 2 models containing 30 rats each with 5 groups per model, Normal control, experimental control, standard and extract treated groups. Standard control was administered with rabeprazole (20mg/kg) and experimental with two doses of extract of EAA at dose of 100mg/kg and 200mg/kg respectively. Ulcers were induced by pylorus ligation and forced swimming for 3 hours. Rats were sacrificed 3 hours after pylorus ligation and forced swimming. Experimental group exhibited significant mucosal injuries, lesions in both models which were reduced in extract groups of 100mg/kg and 200mg/kg. The increase in the levels of catalase and glutathione and decrease in lipid peroxidation in both models proved the antioxidant activity of extract.Thus it can be concluded that ethanolic extract of A. auriculiformis have antiulcer activity, which can be attributed to its antioxidant mechanism of action.

Keywords: A. auriculiformis, gastroprotective, rabeprazole.