INVITRO ANTI-ARTHRITIC EFFECT OF THE LEAVES OF CASSIA FISTULA LINN.

Mahendar Boddupally*, Dr. S. Shobha Rani, A. Thanga Thirupathi, K.N.V. Rao, R. Vasanthi

ABSTRACT

The objective of present work is to study the in-vitro anti-arthritic activity of Cassia fistula linn leaf, a traditional plant of Telangana, India. The ethanolic extract of Cassia fistula linn leaf (EECFL) was studied for In-Vitro anti-arthritic activity by bovine serum protein denaturation method. The activity of ethanolic extract of CFL was compared with standard anti-inflammatory drug Diclofenec. It showed 18.3%, 29.7%,44.4%,69.2%,81.5%,93.1% inhibition of denaturation @ 100,200,400,600,800,1000mcg/ml of bovin serum whereas, standard diclofenac @ 100, 200, 400,600,800,1000 mcg/ml showed 16.8%,27.4%,51.2%, 63.4%,70.6%,89.9% inhibition of denaturation of bovin serum. It was found that ethanolic extract of Cassis fistula linn leaves was more potent in inhibition of egg albumin denaturation than diclofenac. Finally, from results it can be concluded that Cassia fistula linn a traditional plant of Telangana posses good Invitro anti-arthritic activity. By further extensive research, we can explore the medicinal value of Cassia fistula linn leaf.

Keywords: Cassia fistula linn, Arthritis, Protein denaturation, Diclofenac sodium, Bovine serum albumin.