“EVALUATION OF CARDIOPROTECTIVE EFFECT OF COW URINE ARK ON ISOPRENALINE INDUCED MYOCARDIAL INJURY IN WISTAR ALBINO RATS”

Dr. Arunkumar D. Rana, Dr. Bhargav M. Purohit*, Dr. Geeta B. Kharadi, Dr. Vishal K. Vadgama, Dr. Alpeshpuri P. Goswami, Dr. Narendra K. Paliwal, Dr. Chandrabhanu B. Tripathi

ABSTRACT

The present study was conducted to evaluate the cardioprotective effect of Cow urine ark (CUA) by isoprenaline-induced myocardial ischemia in male Wistar albino rats. Acute toxicity study was performed. Chemical analysis of CUA contents was carried out. For present study, total 72 rats were randomized into 6 groups: normal saline, isoprenaline control, CUA, Low dose (1.4 ml/kg) and High dose (2.8 ml/kg) CUA and Carvedilol (1 mg/kg) group. Myocardial injury was produced by subcutaneous injection of isoprenaline (85 mg/kg) on day 27th and 28th. ECG changes, cardiac injury markers, antioxidant markers and histopathological changes were observed. Study results show decrease in troponin - I levels in Low and High dose CUA group as compared to Isoprenaline control group and histopathological changes show statistically significant cardioprotective effect with high dose CUA. So we can conclude that high dose CUA shows the cardioprotective effect but further study with higher doses is necessary.

Keywords: Cardioprotective; Carvedilol; CUA; Isoprenaline; Myocardial injury.